Synthesis and Biological Activity Assessment of Different Diastereomers in siRNA Drug LEQVIO (Inclisiran) (U01) Clinical Trial Not Allowed
Synthesis and Biological Activity Assessment of Different Diastereomers in siRNA Drug LEQVIO (Inclisiran) (U01) Clinical Trial Not Allowed is offered by Food and Drug Administration. Max award: $300,000. This is a forecast; the deadline is not set yet.
| Opportunity number | FOR-FD-24-007 |
|---|---|
| Agency | Food and Drug Administration |
| Status | Forecasted |
| Posted | Nov 24, 2023 |
| Closes | Not set |
| Award ceiling | $300,000 |
| Award floor | $300,000 |
| Total program funding | Not specified |
| Expected awards | 1 |
| Who can apply | Small businesses, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Public and State controlled institutions of higher education, Independent school districts, Native American tribal governments (Federally recognized), Special district governments, City or township governments, For profit organizations other than small businesses, Private institutions of higher education, State governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), Public housing authorities/Indian housing authorities, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, County governments, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility" |
| Category | Agriculture, Consumer Protection, Food and Nutrition |
Summary (excerpt)
The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. The proposed studies will focus on 1) synthesis of each dia…
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